One of the most critical aspects of this is ensuring that you know exactly what you’re consuming. A 2025 review by Kinderlehrer notes that psilocybin and its metabolite psilocin may reduce pro-inflammatory cytokines, modulate serotonin pathways, and support neuroplasticity—effects that could be relevant even at low doses. However, most of this research has been conducted using full psychedelic doses. If you qualify and a GLP-1 medication is prescribed, your clinician will help you start at the right dose, monitor your response, and make thoughtful adjustments along the way.
Legal Status of Microdosing Mushrooms
Proponents say that the practice improves mental health, reduces anxiety, and may even help keep the person focused or creative what is microdosing throughout the day. A 2023 review suggests that microdoses of psilocybin could help to enhance creativity in adults. In contrast, 2025 studies published in Neuropharmacology show that psilocybin has 10 times lower affinity for 5-HT2B receptors than LSD. At doses under 0.25 g of dried mushrooms (less than twice per week), the risk of heart valve disease is statistically negligible (0.3% compared to 8% in frequent LSD users). Overall, the current evidence for the effectiveness of microdosing is mixed.
Uses & Effectiveness
She has a wide range of clinical experiences, ranging from years of traditional clinic practice to hospitalist care to performing peer quality review to ensure optimal patient care. Manne-Goehler is in favor of more research on microdosing but says she's not in favor of "advertising they have benefits we're not sure they really have. But I think testing them for all of those things makes a lot of sense." That doesn't mean they're inherently dangerous, but the drug's strength and quality can vary, along with the behind-the-scenes ethics of more than 100 telehealth companies that prescribe GLP-1s. A service of the National Library of Medicine, PubMed® contains publication information and (in most cases) brief summaries of articles from scientific and medical journals.
- For MDMA, that translates into the range of 10 to 15 milligrams, a fraction of the familiar recreational range of 100 to 125 milligrams.
- I’ve suffered with PTSD, bipolar disorder and anxiety for years and my doctor and my therapist both endorse microdosing for my situation.
- This also means that there isn’t much high quality scientific evidence on the topic.
- There is no set rule as to whether microdosing any psychedelics is a type of substance misuse.
Ozempic microdosing chart
It's important to note that these side effects are dose-dependent and are more likely to occur with larger doses and with inexperienced cannabis users 13. Some individuals may experience heightened feelings of worry or unease, mainly if they are new to cannabis use or if they consume a strain high in THC 11, 12. Microdosing THC, the primary psychoactive compound in cannabis, can still lead to a variety of side effects. These effects can vary from person to person and often depend on the dosage and the individual's tolerance. It can help manage pain, making it a potential alternative to traditional pain medications. The psychoactive actions of THC are primarily mediated by the cannabinoid receptor CB1 4.
FREE 4 Part Video Series on GLP1 Agonists
- Countless telehealth platforms have begun to offer it, with varying angles.
- This interaction can promote neuroplasticity, enhancing brain connectivity and cognitive flexibility, which may lead to improved mood, creativity, and emotional resilience.
- However, despite this strict classification, the FDA has taken important steps that reflect a growing recognition of psilocybin’s therapeutic potential.
If you have a pre-existing heart condition, it’s advised to avoid extended periods of microdosing and monitor your heart functions regularly. In 2022, one doctor mentioned that a patient had gone on Ozempic and their symptoms vanished. This prompted others to try it – but because most of their patients don't want to lose weight, they prescribe microdoses.
If you’re new to microdosing shrooms, it’s important to do thorough research and consult with a medical professional before beginning. Ultimately, the best way to understand what mushrooms feels like is to try it for yourself, starting with a small amount and gradually increasing over time to find the optimal dose for your body. In the case of microdosing shrooms, this means taking a very small amount of psilocybin, the psychoactive compound found in magic mushrooms. Most clinical trials of Ozempic compared once-weekly doses of 0.5 mg and 1 mg for people with type 2 diabetes. The typical starting dose is 0.25 mg once per week for the first month. You can read our Ozempic dosage overview for details about the drug’s dosage and how to use Ozempic pens.
Countless telehealth platforms have begun to offer it, with varying angles. Without robust clinical evidence, it’s difficult to determine whether microdosing offers significant advantages or introduces unnecessary risks. Manufacturer Novo Nordisk Drug rehabilitation has established specific, clinically tested dosages for semaglutide, and microdosing falls outside of these official guidelines.
